We are taking an Easter break between the Easter and ANZAC day long weekends. You can still place orders now, and also while we are on break. If we we receive but don't finish testing your samples before Easter they will be at the top of our list when we re-open.
Spongy cerebellar degeneration with cerebellar ataxia 2 (SDCA2)
Summary
Pups affected by SDCA2 start to show signs of cerebellar degeneration from around four weeks old. They lose coordination, starting to show a wide-based stance and tremors. This worsens rapidly until the pup can no longer walk. They may also be affected by seizures.
SDCA2 is an autosomal recessive disorder. Autosomal disorders are equally likely to affect male or female dogs, while "recessive" means that a dog needs to inherit the SDCA2 mutation from both its parents to be affected.
Dogs that are carriers for SDCA2 are not affected themselves but can potentially produce affected pups. They should not be bred to other carriers.
Gene or region and technical reference
Gene: ATP1B2 (causative). Reference: Mauri et al. (2017)
Reported alleles
n. Test developed using artificial DNA, animal controls.
SCDA2. Test developed using articifial DNA.
Panels: groups of tests that are often ordered together
This test is in the Belgian Shepherd health mini-panel.
