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Trapped neutrophil syndrome (TNS)

Summary

Trapped neutrophil syndrome (TNS) is a disorder that impacts the immune system. Dogs with TNS can show early infections starting at around six weeks of age, react badly to immunisation, or be smaller than their litter mates. They usually struggle with frequent or ongoing infections, and most end up being euthanised.

TNS is found in all lines of border collies and may also be present in working Kelpies due to interbreeding in the past.

TNS is an autosomal recessive disorder. Autosomal disorders are equally likely to affect male or female dogs, while "recessive" means that a dog needs to inherit the TNS mutation from both its parents to be affected.

Gene or region and technical reference

Gene: VPS13B (causative). Reference: Shearman and Wilton, 2011.

Reported alleles

n. Test developed using artificial DNA and animal controls.

TNS. Test developed using artificial DNA and animal cases.

Panels: groups of tests that are often ordered together

This test is in the working dog core panel.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Panels


Colour panels

$24 B locus ... more

$16 E locus ... more


Working dogs

$59 Australian Kelpie panel ... more

$26 Working dog CA (CA panel) ... more

$54 Working dog core panel ... more


Good looks


Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Improper coat ... more


Good health


Australian Kelpies

$14 Intestinal lipid malabsorption (ILM) ... more


Good looks


Coat colour

$9 B locus brown (bc allele) (bc) ... more

$9 B locus brown (bd allele) (bd) ... more

$9 B locus brown (bs allele) (bs) ... more

$9 D locus dilute d2 (Chow Chow type) (d2) ... more

$9 E locus melanistic mask ... more

$9 E locus red/black ... more


Good health


Multiple breeds

$14 Degenerative myelopathy (DM) ... more

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more


Working dogs

$14 Cerebellar abiotrophy marker (LINGO3) (CA: LINGO3) ... more

$14 Cerebellar abiotrophy marker (VMP1) (CA: VMP1) ... more

$14 Collie eye anomaly (CEA) ... more

$14 Trapped neutrophil syndrome (TNS)

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.