Dry eye/curly coat syndrome (CKCS) (CKCSID)

Summary

Dry eye/curly coat is the name given to an inherited syndrome in some Cavalier King Charles Spaniels pups. It's also called congenital keratoconjunctivitis sicca and ichthyosiform dermatosis. It causes serious health problems that affect the eyes, skin, coat and paws from birth, getting worse as the puppy grows. Eye and skin problems may cause vision issues and itchy skin, respectively. Paw issues can be painful for the puppy and make it hard to walk.

Unfortunately, there's no cure for this syndrome. Managing it is difficult, and some owners choose to have their puppies put down due to poor quality of life. Testing for the mutant form of the FAM83H gene, which causes this syndrome, can help breeders avoid producing affected pups.

This syndrome requires two copies of the mutant FAM83H gene, one from each parent, to develop in dogs. It affects both males and females equally. Carriers (one copy) won't have this syndrome, but can pass the gene on to offspring.

Gene or region and technical reference

Gene: FAM83H (causative). Reference: Forman et al. (2012)

Reported alleles

n. Test developed using artificial DNA, animal controls.

CKCSID. Test developed using artificial DNA.

Panels: groups of tests that are often ordered together

This test is not in any panels.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Panels


Colour panels

$24 B locus ... more

$35 Coat type ... more

$16 D locus ... more

$16 E locus ... more


Working dogs

$59 Australian Kelpie panel ... more

$26 Working dog CA ... more

$54 Working dog core panel ... more


Good looks


Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Improper coat ... more

$14 Shedding ... more


Coat colour

$9 B locus brown (bc allele) (bc) ... more

$9 B locus brown (bd allele) (bd) ... more

$9 B locus brown (bs allele) (bs) ... more

$9 D locus dilute d (common type) (d) ... more

$9 D locus dilute d2 (Chow Chow type) (d2) ... more

$9 E locus melanistic mask ... more

$9 E locus red/black ... more

$9 K locus dominant black ... more


Good health


Australian Kelpies

$14 Intestinal lipid malabsorption (ILM) ... more


Good health


Multiple breeds

$14 Airways oedema ... more

$14 Degenerative myelopathy (DM) ... more

$14 Hyperuricosuria (HUU) ... more

$14 Ivermectin and multidrug sensitivity ... more

$14 Myxomatous mitral valve disease (MMVD) ... more

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more

$14 Progressive retinal atrophy CORD1 (PRA-cord1) ... more

$14 Screw tail ... more


Pure- and part-bred CKCS

$14 Congenital macrothrombocytopenia (CKCS type) (CM) ... more

$14 Dry eye/curly coat syndrome (CKCS) (CKCSID)

$14 Episodic falling syndrome (CKCS) (EF) ... more

$14 Medium-chain acyl co-A dehydrogenase deficiency (CKCS) (MCADD) ... more

$14 Myxomatous mitral valve disease (MMVD) ... more


Pure- and part-bred Labradors

$14 Labrador centronuclear myopathy (CNM) ... more

$14 Labrador exercise induced collapse (EIC) ... more

$14 Labrador hereditary nasal parakeratosis (HNPK) ... more


Pure- and part-bred NSDTR

$14 Cleft lip/palate and syndactyly (CLPS) ... more

$14 Cleft palate (CP1) ... more


Working dogs

$14 Cerebellar abiotrophy marker (LINGO3) (CA LINGO3) ... more

$14 Cerebellar abiotrophy marker (VMP1) (CA VMP1) ... more

$14 Collie eye anomaly (CEA) ... more

$14 Trapped neutrophil syndrome (TNS) ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.