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Ivermectin and multidrug sensitivity

Summary

Multidrug sensitivity is often called ivermectin sensitivity and is most commonly found in Collie breeds and crossbred dogs.

Dogs with multidrug sensitivity can be poisoned by low doses of ivermectin or a range of other drugs and medications. You should let your vet know if you discover your dog is affected or a carrier for this disorder.

Multidrug sensitivity is an autosomal recessive disorder. Autosomal disorders can affect male or female dogs, while "recessive" means that a dog needs to inherit the multidrug sensitivity mutation from both parents to be affected. Carriers (dogs with an MDR1 n result) can safely be bred to clear dogs (those with an n n result) with no risk of producing affected pups. Carriers should not be bred to other carriers.

Gene or region and technical reference

Gene: ABCB1 (MDR1) (causative). Reference: Mealey et al. (2001)

Reported alleles

n. Test developed using artificial DNA, animal controls.

MDR1. Test developed using artificial DNA.

Panels: groups of tests that are often ordered together

This test is in the working dog core panel.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Panels


Colour panels

$24 B locus ... more

$35 Coat type ... more

$16 D locus ... more

$16 E locus ... more


Working dogs

$59 Australian Kelpie panel ... more

$26 Working dog CA ... more

$54 Working dog core panel ... more


Good looks


Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Improper coat ... more

$14 Shedding ... more


Coat colour

$9 B locus brown (bc allele) (bc) ... more

$9 B locus brown (bd allele) (bd) ... more

$9 B locus brown (bs allele) (bs) ... more

$9 D locus dilute d (common type) (d) ... more

$9 D locus dilute d2 (Chow Chow type) (d2) ... more

$9 E locus melanistic mask ... more

$9 E locus red/black ... more

$9 K locus dominant black ... more


Good health


Australian Kelpies

$14 Intestinal lipid malabsorption (ILM) ... more


Multiple breeds

$14 Airways oedema ... more

$14 Degenerative myelopathy (DM) ... more

$14 Hyperuricosuria (HUU) ... more

$14 Ivermectin and multidrug sensitivity

$14 Myxomatous mitral valve disease (MMVD) ... more

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more

$14 Progressive retinal atrophy CORD1 (PRA-cord1) ... more

$14 Screw tail ... more


Pure- and part-bred Labradors

$14 Labrador centronuclear myopathy (CNM) ... more

$14 Labrador hereditary nasal parakeratosis (HNPK) ... more


Pure- and part-bred NSDTR

$14 Cleft lip/palate and syndactyly (CLPS) ... more

$14 Cleft palate (CP1) ... more


Working dogs

$14 Cerebellar abiotrophy marker (LINGO3) (CA LINGO3) ... more

$14 Cerebellar abiotrophy marker (VMP1) (CA VMP1) ... more

$14 Collie eye anomaly (CEA) ... more

$14 Trapped neutrophil syndrome (TNS) ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.