Progressive retinal atrophy CORD1 (PRA-cord1)
Summary
PRA-cord1 is a disorder where dogs can lose their vision or have severely degraded vision starting from a very early age.
This disorder is most commonly found in Dachshund and English Springer Spaniel dogs. It is also in a range of other breeds, including French Bulldogs.
Not all dogs that test as affected for PRA-cord1 will lose their vision. Research suggests that the loss of vision requires an interaction between this gene and a second one. Unfortunately a test is not yet available for this second gene.
PRA-cord1 is an autosomal recessive disorder. Autosomal disorders are equally likely to affect male or female dogs, while "recessive" means that a dog needs to inherit the PRA-cord1 mutation from both its sire and its dam to be affected. Dogs that carry only one copy of this gene are not affected by this disorder, but can produce affected pups.
Gene or region and technical reference
Gene: CORD1 (marker). Reference: Mellersh et al (2006)
Reported alleles
n. Test developed using artificial DNA, animal controls.
PRA-cord1. Test developed using artificial DNA, animal cases.
Panels: groups of tests that are often ordered together
This test is not in any panels.
