Cleft lip/palate and syndactyly (CLPS)

Summary

A cleft palate occurs when the roof of the mouth (palate) doesn't fully fuse during development before birth, leaving a gap. Cleft palate severity varies but can be life-threatening in some cases. "Syndactyly" refers to a puppy being born with toes that are fused together. It can range from mild webbing between toes to complete fusion, impacting both appearance, mobility and sometimes quality of life.

Testing can help identify dogs who carry the mutant form of the gene that causes cleft palate (with syndactyly). There is a separate genetic test for cleft palate (CP1).

Cleft palate/syndactyly is an autosomal recessive disorder. Autosomal disorders are equally likely to affect male or female dogs. ôRecessive" means that a dog must inherit the mutant form of the gene from both its parents to be affected. Dogs with one copy of the gene will not be affected. However, they could pass the gene on to offspring.

Gene or region and technical reference

Gene: ADAMTS20 (causative). Reference: Wolf et al. (2014)

Reported alleles

n. Test developed using artificial DNA, animal controls.

CLPS. Test developed using artificial DNA, animal carriers.

Panels: groups of tests that are often ordered together

This test is not in any panels.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Panels


Colour panels

$24 B locus ... more

$35 Coat type ... more

$16 D locus ... more

$16 E locus ... more


Working dogs

$59 Australian Kelpie panel ... more

$26 Working dog CA ... more

$54 Working dog core panel ... more


Good looks


Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Improper coat ... more

$14 Shedding ... more


Coat colour

$9 B locus brown (bc allele) (bc) ... more

$9 B locus brown (bd allele) (bd) ... more

$9 B locus brown (bs allele) (bs) ... more

$9 D locus dilute d (common type) (d) ... more

$9 D locus dilute d2 (Chow Chow type) (d2) ... more

$9 E locus melanistic mask ... more

$9 E locus red/black ... more

$9 K locus dominant black ... more


Good health


Australian Kelpies

$14 Intestinal lipid malabsorption (ILM) ... more


Good health


Multiple breeds

$14 Airways oedema ... more

$14 Degenerative myelopathy (DM) ... more

$14 Hyperuricosuria (HUU) ... more

$14 Ivermectin and multidrug sensitivity ... more

$14 Myxomatous mitral valve disease (MMVD) ... more

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more

$14 Progressive retinal atrophy CORD1 (PRA-cord1) ... more

$14 Screw tail ... more


Pure- and part-bred CKCS

$14 Congenital macrothrombocytopenia (CKCS type) (CM) ... more

$14 Dry eye/curly coat syndrome (CKCS) (CKCSID) ... more

$14 Episodic falling syndrome (CKCS) (EF) ... more

$14 Medium-chain acyl co-A dehydrogenase deficiency (CKCS) (MCADD) ... more

$14 Myxomatous mitral valve disease (MMVD) ... more


Pure- and part-bred Labradors

$14 Labrador centronuclear myopathy (CNM) ... more

$14 Labrador exercise induced collapse (EIC) ... more

$14 Labrador hereditary nasal parakeratosis (HNPK) ... more


Pure- and part-bred NSDTR

$14 Cleft lip/palate and syndactyly (CLPS)

$14 Cleft palate (CP1) ... more


Working dogs

$14 Cerebellar abiotrophy marker (LINGO3) (CA LINGO3) ... more

$14 Cerebellar abiotrophy marker (VMP1) (CA VMP1) ... more

$14 Collie eye anomaly (CEA) ... more

$14 Trapped neutrophil syndrome (TNS) ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.