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Congenital macrothrombocytopenia (CKCS type) (CM)

Summary

Some Cavalier King Charles Spaniels (CKCSs) have an unusual feature in their blood known as congenital macrothrombocytopenia (CM). This means their blood has large platelets (clumping cells that help stop bleeding) that are fewer in number than in most other dogs. These large platelets still work normally and don't cause any bleeding problems for the dog. CM does not require treatment. However, CM can make it look like a serious bleeding disorder on a blood test.

You should tell your vet if your dog has the mutant form of the ?1-tubulin gene which causes CM to avoid misdiagnosis and unnecessary treatments. The result of this gene test may also inform your breeding choices.

CM requires two copies of the mutant ?1-tubulin gene, one from each parent, to develop in dogs. It affects both males and females equally. Carriers (with one copy) won't have CM but can pass the gene on to offspring.

Gene or region and technical reference

Gene: TUBB1 (causative). Reference: Davis et al. (2008)

Reported alleles

n. Test developed using artificial DNA, animal controls.

CM. Test developed using artificial DNA, animal cases.

Panels: groups of tests that are often ordered together

This test is in the CKCS health mini-panel.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Panels


Colour panels

$24 B locus ... more

$35 Coat type ... more

$16 D locus ... more

$16 E locus ... more


Panels by breed

$80 CKCS health mini-panel ... more


Working dogs

$59 Australian Kelpie panel ... more

$26 Working dog CA ... more

$54 Working dog core panel ... more


Good looks


Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Curly coat type 2 ... more

$9 Improper coat ... more

$14 Shedding ... more


Coat colour

$9 B locus brown (bc allele) (bc) ... more

$9 B locus brown (bd allele) (bd) ... more

$9 B locus brown (bs allele) (bs) ... more

$9 D locus dilute d (common type) (d) ... more

$9 D locus dilute d2 (Chow Chow type) (d2) ... more

$9 E locus melanistic mask ... more

$9 E locus red/black ... more

$9 I locus intensity dilution ... more

$9 K locus dominant black ... more


Good health


Australian Kelpies

$14 Intestinal lipid malabsorption (ILM) ... more


Good health


Multiple breeds

$14 Airways oedema ... more

$14 Congenital multifocal retinopathy 1 (Mastiff type) (CMR1) ... more

$14 Degenerative myelopathy (DM) ... more

$14 Hyperuricosuria (HUU) ... more

$14 Ivermectin and multidrug sensitivity ... more

$14 Myxomatous mitral valve disease (MMVD) ... more

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more

$14 Progressive retinal atrophy CORD1 (PRA-cord1) ... more


Pure- and part-bred CKCS

$14 Congenital macrothrombocytopenia (CKCS type) (CM)

$14 Curly coat/dry eye syndrome (CKCS) (CKCSID) ... more

$14 Episodic falling syndrome (CKCS) (EF) ... more

$14 Medium-chain acyl co-A dehydrogenase deficiency (CKCS) (MCADD) ... more

$14 Myxomatous mitral valve disease (MMVD) ... more


Pure- and part-bred Labradors

$14 Labrador centronuclear myopathy (CNM) ... more

$14 Labrador exercise induced collapse (EIC) ... more

$14 Labrador hereditary nasal parakeratosis (HNPK) ... more


Pure- and part-bred NSDTR

$14 Cleft lip/palate and syndactyly (CLPS) ... more

$14 Cleft palate (CP1) ... more


Pure- and part-bred bulldog breeds

$26 Cystinuria (Bulldog risk markers) ... more

$14 Screw tail ... more


Working dogs

$14 Cerebellar abiotrophy marker (LINGO3) (CA LINGO3) ... more

$14 Cerebellar abiotrophy marker (VMP1) (CA VMP1) ... more

$14 Collie eye anomaly (CEA) ... more

$14 Trapped neutrophil syndrome (TNS) ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.