Myxomatous mitral valve disease (MMVD)
Summary
This test is based on recent research that identified genetic variants associated with increased risk of early-onset myxomatous mitral valve disease (MMVD). It determines a dog's genotype for the genetic variant referred to as NEBL3 in the Axelsson paper referenced below.
Dogs with a G G or A G test result are less likely to be diagnosed with MMVD early in life compared to dogs with an A A result. Very few Cavalier King Charles Spaniels have the G variant, and identifying these dogs could help breeders who want to produce healthier pups.
The test was developed based on data from Cavalier King Charles Spaniel and Dachshund dogs and should not be used on other dog breeds. The test is likely to be updated if further research suggests other genetic variants are more useful predictors of MMVD severity or time of onset.Gene or region and technical reference
Gene: NEBL (marker). Reference: Axelsson et al. (2021), Mead et al. (2022)
Reported alleles
G. Test developed using artificial DNA, animal controls.
A. Test developed using artificial DNA, animal carriers.
Panels: groups of tests that are often ordered together
This test is in the CKCS health mini-panel.
