Chondrodystrophy (CDDY/IVDD)

Summary

This insertion on CFA12 causes short legs. It also causes big ears and a substantial increase in the risk of developing inter-vertebral disk disease (IVDD). A similar insertion on CFA18 causes short legs but without so much risk of IVDD.

This insertion was identified in NSDTRs while the other one is responsible for short legs in daschunds and some other small dog breeds.

Gene or region and technical reference

Gene: CFA12 FGF4 retrogene (causative). Reference: Brown et al, 2017

Reported alleles

n. Test developed using artificial DNA, animal controls.

CDDY. Test developed using artificial DNA, animal cases.

Panels: groups of tests that are often ordered together

This test is in the British bulldog health mini-panel.

This test is in the French bulldog health mini-panel.