Congenital multifocal retinopathy 1 (Mastiff type) (CMR1)
Summary
Congenital multifocal retinopathy (CMR) is an eye disease that most commonly affects bulldogs, but can also be found in other breeds. It causes lesions (spots) on the retina (the layers of nerve tissue at the back of the eye). These can only be picked up with an eye examination. It usually appears in pups from about four months old onwards. CMR may or may not affect your dog's vision; it largely depends on the size of the lesions.
A mutant form of the VMD2 gene causes CMR. Testing for this form of the gene will help inform your breeding choices.
CMR requires two copies of the VMD2 gene, one from each parent, to develop in dogs. It affects both males and females equally. Carriers (one copy) won’t have CMR but can pass the gene on to offspring.
Gene or region and technical reference
Gene: VMD2 (causative). Reference: Guziewicz et al., 2007
Reported alleles
n. Test developed using artificial DNA, animal controls.
CMR1. Test developed using artificial DNA.
Panels: groups of tests that are often ordered together
This test is not in any panels.
