Medium-chain acyl co-A dehydrogenase deficiency (CKCS) (MCADD)

Summary

Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a condition in Cavalier King Charles Spaniels, which affects how they break down certain fats for energy. If a dog has MCADD, they may not be able to get the energy they need when they need it. This may result in low blood sugar, seizures, coma or even sudden death.

MCADD can be managed by changing diet (avoiding certain oils), so it's crucial to find out if your dog has the mutant form of the ACADM gene. Testing will also help inform your breeding choices.

MCADD requires two copies of the variant ACADM gene, one from each parent, to develop in dogs. It affects both males and females equally. Carriers (one copy) won't have MCADD but can pass the gene on to offspring.

Gene or region and technical reference

Gene: ACADM (causative). Reference: Christen et al, 2022

Reported alleles

n. Test developed using artificial DNA, animal controls.

MCADD. Test developed using artificial DNA, animal carriers.

Panels: groups of tests that are often ordered together

This test is in the CKCS health mini-panel.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Panels


Colour panels

$24 B locus ... more

$35 Coat type ... more

$16 D locus ... more

$16 E locus ... more


Panels by breed

$80 CKCS health mini-panel ... more


Working dogs

$59 Australian Kelpie panel ... more

$26 Working dog CA ... more

$54 Working dog core panel ... more


Good looks


Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Curly coat type 2 ... more

$9 Improper coat ... more

$14 Shedding ... more


Coat colour

$9 B locus brown (bc allele) (bc) ... more

$9 B locus brown (bd allele) (bd) ... more

$9 B locus brown (bs allele) (bs) ... more

$9 D locus dilute d (common type) (d) ... more

$9 D locus dilute d2 (Chow Chow type) (d2) ... more

$9 E locus melanistic mask ... more

$9 E locus red/black ... more

$9 I locus intensity dilution ... more

$9 K locus dominant black ... more


Good health


Australian Kelpies

$14 Intestinal lipid malabsorption (ILM) ... more


Good health


Multiple breeds

$14 Airways oedema ... more

$14 Congenital multifocal retinopathy 1 (Mastiff type) (CMR1) ... more

$14 Degenerative myelopathy (DM) ... more

$14 Hyperuricosuria (HUU) ... more

$14 Ivermectin and multidrug sensitivity ... more

$14 Myxomatous mitral valve disease (MMVD) ... more

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more

$14 Progressive retinal atrophy CORD1 (PRA-cord1) ... more


Pure- and part-bred CKCS

$14 Congenital macrothrombocytopenia (CKCS type) (CM) ... more

$14 Curly coat/dry eye syndrome (CKCS) (CKCSID) ... more

$14 Episodic falling syndrome (CKCS) (EF) ... more

$14 Medium-chain acyl co-A dehydrogenase deficiency (CKCS) (MCADD)

$14 Myxomatous mitral valve disease (MMVD) ... more


Pure- and part-bred Labradors

$14 Labrador centronuclear myopathy (CNM) ... more

$14 Labrador exercise induced collapse (EIC) ... more

$14 Labrador hereditary nasal parakeratosis (HNPK) ... more


Pure- and part-bred NSDTR

$14 Cleft lip/palate and syndactyly (CLPS) ... more

$14 Cleft palate (CP1) ... more


Pure- and part-bred bulldog breeds

$26 Cystinuria (Bulldog risk markers) ... more

$14 Screw tail ... more


Working dogs

$14 Cerebellar abiotrophy marker (LINGO3) (CA LINGO3) ... more

$14 Cerebellar abiotrophy marker (VMP1) (CA VMP1) ... more

$14 Collie eye anomaly (CEA) ... more

$14 Trapped neutrophil syndrome (TNS) ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.