Medium-chain acyl co-A dehydrogenase deficiency (CKCS) (MCADD)
Summary
Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a condition in Cavalier King Charles Spaniels, which affects how they break down certain fats for energy. If a dog has MCADD, they may not be able to get the energy they need when they need it. This may result in low blood sugar, seizures, coma or even sudden death.
MCADD can be managed by changing diet (avoiding certain oils), so it's crucial to find out if your dog has the mutant form of the ACADM gene. Testing will also help inform your breeding choices.
MCADD requires two copies of the variant ACADM gene, one from each parent, to develop in dogs. It affects both males and females equally. Carriers (one copy) won't have MCADD but can pass the gene on to offspring.
Gene or region and technical reference
Gene: ACADM (causative). Reference: Christen et al, 2022
Reported alleles
n. Test developed using artificial DNA, animal controls.
MCADD. Test developed using artificial DNA, animal carriers.
Panels: groups of tests that are often ordered together
This test is in the CKCS health mini-panel.
