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Myxomatous mitral valve disease (MMVD)

Summary

This test is based on recent research that identified genetic variants associated with increased risk of early-onset myxomatous mitral valve disease (MMVD). It determines a dog's genotype for the genetic variant referred to as NEBL3 in the scientific paper referenced below.

Dogs with a G G or A G test result are less likely to be diagnosed with MMVD early in life compared to dogs with an A A result. Very few Cavalier King Charles Spaniels have the G variant, and identifying these dogs could help breeders who want to produce healthier pups.

The test was developed based on data from Cavalier King Charles Spaniel and Dachshund dogs and should not be used on other dog breeds. The test is likely to be updated if further research suggests other genetic variants are more useful predictors of MMVD severity or time of onset.

Gene or region and technical reference

Gene: NEBL (marker). Reference: Axelsson et al. (2021)

Reported alleles

G. Test developed using artificial DNA, animal controls.

A. Test developed using artificial DNA, animal carriers.

Panels: groups of tests that are often ordered together

This test is not in any panels.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Panels


Colour panels

$24 B locus ... more

$16 D locus ... more

$16 E locus ... more


Working dogs

$59 Australian Kelpie panel ... more

$26 Working dog CA ... more

$54 Working dog core panel ... more


Good looks


Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Improper coat ... more


Good health


Australian Kelpies

$14 Intestinal lipid malabsorption (ILM) ... more


Pure- and part-bred Labradors

$14 Labrador centronuclear myopathy (CNM) ... more


Good looks


Coat colour

$9 B locus brown (bc allele) (bc) ... more

$9 B locus brown (bd allele) (bd) ... more

$9 B locus brown (bs allele) (bs) ... more

$9 D locus dilute d (common type) (d) ... more

$9 D locus dilute d2 (Chow Chow type) (d2) ... more

$9 E locus melanistic mask ... more

$9 E locus red/black ... more


Good health


Multiple breeds

$14 Airways oedema ... more

$14 Degenerative myelopathy (DM) ... more

$14 Hyperuricosuria (HUU) ... more

$14 Myxomatous mitral valve disease (MMVD)

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more

$14 Progressive retinal atrophy CORD1 (PRA-cord1) ... more

$14 Screw tail ... more


Working dogs

$14 Cerebellar abiotrophy marker (LINGO3) (CA: LINGO3) ... more

$14 Cerebellar abiotrophy marker (VMP1) (CA: VMP1) ... more

$14 Collie eye anomaly (CEA) ... more

$14 Trapped neutrophil syndrome (TNS) ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.