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Hyperuricosuria (HUU)
Summary
Hyperuricosuria is a disorder where dogs produce high amount of uric acid in their urine. This in turn can lead to bladder and kidney stones. Owners might notice that their dogs urinate even more than other dogs (yes, really), or that they struggle to urinate, have blood in their urine, or are depressed and reluctant to move.
Hyperuricosuria is most common in Dalmation dogs but can occur in a range of dogs including but not limited to British Bulldogs, French Bulldogs and Staffordshire Terriers.
Hyperuricosuria is an autosomal recessive disorder. Autosomal disorders are equally likely to affect male or female dogs, while "recessive" means that a dog needs to inherit the HUU mutation from both its sire and its dam to be affected. Dogs that carry only one copy of this gene are not affected by this disorder, but can produce affected pups.
Gene or region and technical reference
Gene: SLC2A9 (causative). Reference: Bannasch et al. (2008)
Reported alleles
n. Test developed using artificial DNA, animal controls.
HUU. Test developed using artificial DNA, animal carriers.
Panels: groups of tests that are often ordered together
This test is not in any panels.
