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Labrador centronuclear myopathy (CNM)

Summary

Puppies born with this type of centronuclear myopathy (the Labrador type) appear healthy at birth but develop problems that become increasingly clear as they mature. The most common sign of problems is the dog being smaller and weaker than its littermates, because this disorder affects the muscles. As the dog grows it may move awkwardly and struggle or collapse in cold weather.

Some dogs are more severely affected than others. They can have difficulty swallowing and frequently regurgitate, which in turn causes more problems.

Centronuclear myopathy (the Labrador type) is an autosomal recessive disorder. Autosomal disorders are equally likely to affect male or female dogs, while "recessive" means that the dog needs to inherit the CNM gene from both parents to be affected.

Gene or region and technical reference

Gene: PTPLA (causative). Reference: Pelé et al., 2005, Maurer et al., 2012

Reported alleles

n. Test developed using artificial DNA, animal controls.

CNM. Test developed using artificial DNA.

Panels: groups of tests that are often ordered together

This test is not in any panels.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Panels


Colour panels

$24 B locus ... more

$16 D locus ... more

$16 E locus ... more


Working dogs

$59 Australian Kelpie panel ... more

$26 Working dog CA ... more

$54 Working dog core panel ... more


Good looks


Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Improper coat ... more


Good health


Australian Kelpies

$14 Intestinal lipid malabsorption (ILM) ... more


Pure- and part-bred Labradors

$14 Labrador centronuclear myopathy (CNM)


Good looks


Coat colour

$9 B locus brown (bc allele) (bc) ... more

$9 B locus brown (bd allele) (bd) ... more

$9 B locus brown (bs allele) (bs) ... more

$9 D locus dilute d (common type) (d) ... more

$9 D locus dilute d2 (Chow Chow type) (d2) ... more

$9 E locus melanistic mask ... more

$9 E locus red/black ... more


Good health


Multiple breeds

$14 Airways oedema ... more

$14 Degenerative myelopathy (DM) ... more

$14 Hyperuricosuria (HUU) ... more

$14 Myxomatous mitral valve disease (MMVD) ... more

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more

$14 Progressive retinal atrophy CORD1 (PRA-cord1) ... more

$14 Screw tail ... more


Working dogs

$14 Cerebellar abiotrophy marker (LINGO3) (CA: LINGO3) ... more

$14 Cerebellar abiotrophy marker (VMP1) (CA: VMP1) ... more

$14 Collie eye anomaly (CEA) ... more

$14 Trapped neutrophil syndrome (TNS) ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.