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Cerebellar abiotrophy marker (LINGO3) (CA: LINGO3)


Cerebellar abiotrophy (CA) has been reported in working Kelpies. Dogs affected by CA can show head or neck tremors, problems with their balance, exaggerated or erratic leg movement and problems eating or drinking from a bowl.

This test (CA: LINGO3) is associated with a form of CA that usually becomes evident in pups between 4 and 8 weeks of age.

A positive result for this test (T T) does not guarantee that your pup will develop early-onset CA, but it is a strong guide. In the original study, 16 of 19 affected pups had a T T result for this marker, while only 19 of 146 healthy dogs showed the same T T result.

The other possible results for this test are T C or C C. Dogs with a C T result do not have a high risk of CA but can potentially produce T T pups.

This form of CA has been found in border collies as well as Kelpies.

Gene or region and technical reference

Gene: LINGO3 (marker). Reference: Pan. (2017) Thesis

Reported alleles

C. Test developed using manufactured DNA, animal controls.

T. Test developed using manufactured DNA, animal cases.

Panels: groups of tests that are often ordered together

This test is in the working dog CA panel.


CA can become obvious in pups as young as 4 weeks old.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


$33 A DNA profile ... more


Colour panels

$25 Brown coat colour ... more

Working dogs

$40 Working dog CA (CA panel) ... more

Good looks

Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Improper coat ... more

Good looks

Coat colour

$9 Brown (bc allele) ... more

$9 Brown (bd allele) ... more

$9 Brown (bs allele) ... more

$9 Dilution type 2 ... more

Good health

Multiple breeds

$14 Collie eye anomaly (CEA) ... more

$14 Degenerative myelopathy (DM) ... more

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more

Working dogs

$14 Cerebellar abiotrophy marker (LINGO3) (CA: LINGO3)

$14 Cerebellar abiotrophy marker (NUP153) (CA: NUP153) ... more

$14 Cerebellar abiotrophy marker (VMP1) (CA:VMP1) ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.