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Collie eye anomaly (CEA)

Summary

Collie eye anomoaly (CEA) can cause total or partial blindness and occasionally bleeding inside the eye. It is also called choroidal hypoplasia.

The choroid is a layer of tissue under the retina with lots of blood vessels. In dogs with CEA it does not develop properly. In most cases the abnormal choroid is present at birth and can be seen in an eye examination at 4-8 weeks of age.

CEA is an autosomal recessive disorder. Autosomal disorders are equally likely to affect male or female dogs, while "recessive" means that a dog needs to inherit the CEA mutation from both its parents to be affected. Some dogs that inherit the CEA mutation from both parents are unaffected. This is why we categorise this test as a marker rather than a causative mutation.

Gene or region and technical reference

Gene: NHEJ1 (marker). Reference: Parker et al. (2017)

Reported alleles

n. Test developed using manufactured DNA, animal controls.

CEA. Test developed using manufactured DNA, animal cases.

Panels: groups of tests that are often ordered together

This test is not in any panels.


dog

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Pedigree

$33 A DNA profile ... more


Panels


Colour panels

$25 Brown coat colour ... more


Working dogs

$40 Working dog CA (CA panel) ... more


Good looks


Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Improper coat ... more


Good looks


Coat colour

$9 Brown (bc allele) ... more

$9 Brown (bd allele) ... more

$9 Brown (bs allele) ... more

$9 Dilution type 2 ... more


Good health


Multiple breeds

$14 Collie eye anomaly (CEA)

$14 Degenerative myelopathy (DM) ... more

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more


Working dogs

$14 Cerebellar abiotrophy marker (LINGO3) (CA: LINGO3) ... more

$14 Cerebellar abiotrophy marker (NUP153) (CA: NUP153) ... more

$14 Cerebellar abiotrophy marker (VMP1) (CA:VMP1) ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.