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Cerebellar abiotrophy marker (NUP153) (CA NUP153)
Summary
Cerebellar abiotrophy (CA) has been reported in working Kelpies. Dogs affected by CA can show head or neck tremors, problems with their balance, exaggerated or erratic leg movement and problems eating or drinking from a bowl.
This test (CA: NUP153) is associated with a form of CA found in a litter of working Kelpies in Germany. In this litter pups showed signs of CA at approximately four weeks of age.
Results for this test are del del (possibly affected), del n (carrier) or n n. Dogs with a del n result do not have a high risk of CA but can potentially produce del del pups.
This test has been removed from the working dog CA panel because it may not predictive of CA for dogs outside the original affected family.
Gene or region and technical reference
Gene: NUP153 (marker). Reference: Pan. (2017) Thesis
Reported alleles
n. Test developed using manufactured DNA, animal controls.
del. Test developed using manufactured DNA, animal cases.
Panels: groups of tests that are often ordered together
This test is not in any panels.
It is not known how common this form of CA is in Australian working Kelpies.