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Cerebellar abiotrophy (NUP153) (CA: NUP153)

Summary

Cerebellar abiotrophy (CA) has been reported in working Kelpies. Dogs affected by CA can show head or neck tremors, problems with their balance, exaggerated or erratic leg movement and problems eating or drinking from a bowl.

This test (CA: NUP153) is associated with a form of CA found in a family of German working Kelpies that were originally imported from Australia.

A positive result for this test (del del) does not guarantee that your dog will develop CA, but it is a strong guide. In the original study, all four CA-affected dogs in this family had a del del result for this marker, while only 2 of 19 other dogs in the same family showed the same del del result. It is not known if those two dogs went on to develop CA later.

Other possible results for this test are del n or n n. Dogs with a del n result do not have a high risk of CA but can potentially produce del del pups.

Gene or region and technical reference

Gene: NUP153 (marker). Reference: Pan. (2017) Thesis

Reported alleles

n. Test developed using manufactured DNA, animal controls.

del. Test developed using manufactured DNA, animal cases.

Panels: groups of tests that are often ordered together

This test is in the working dog CA panel.


dog

It is not known how common this form of CA is in Australian working Kelpies.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Pedigree

$33 A DNA profile ... more


Panels


Colour panels

$25 Brown coat colour ... more


Working dogs

$40 Working dog CA (CA panel) ... more


Good looks


Coat characteristics

$9 Coat length L (common form) (L) ... more

$9 Coat length L2 (L2) ... more

$9 Curly coat ... more

$9 Improper coat ... more


Good looks


Coat colour

$9 Brown (bc allele) ... more

$9 Brown (bd allele) ... more

$9 Brown (bs allele) ... more

$9 Dilution type 2 ... more


Good health


Multiple breeds

$14 Degenerative myelopathy (DM) ... more

$14 Progressive retinal atrophy - PRCD (PRA-PRCD) ... more


Working Kelpies

$14 Cerebellar abiotrophy (LINGO3) (CA: LINGO3) ... more

$14 Cerebellar abiotrophy (NUP153) (CA: NUP153)

$14 Cerebellar abiotrophy (VMP1) (CA: VMP1) ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.